Class: Lipases
Format: Immobilized
Sustine® 110 IM
Novonesis Sustine® 110 IM is a non-specific immobilized lipase that offers cost-efficient recyclability and works well with stereoselective hydrolysis of esters, transesterification and esterification of acids, and acylation of amines.
The biocatalytic properties of Sustine® 110 IM are already being used in the manufacturing of known commercial active pharmaceutical ingredients (APIs), such as:
- Molnupiravir
- Trandolapril
- Amino hydroxypiperidine derivatives
- Pimecrolimus
It is also used as a catalyst to manufacture key agro intermediates (AIs):
- S-metolachlor and S-dimethenamid – Herbicide intermediate (S)-MOIPA
Other commercial APIs/AIs that use Sustine® 110 IM include:
- Moxifloxacin
- Posaconazole
- S-Flurbiprofen
- Ketorolac
- Chloramphenicol
- Analogues of mevinic acid
- (S)-1-(2-furyl)ethanol
- Intermediates in the synthesis of Stagonolide E, Pyrenophorol and Decarestrictin L
- Naphthofurandion derivative
Sustine® 110 IM is identical to the former Novozymes product, Novozym® 435.
Product features, details and benefits
- Recyclable
Stereoselective hydrolysis of esters, transesterification, and esterification of acids, and acylation of amines.
- Broad specificity
Immobilized granulate (Yes)
- Very broad temperature stability (up to 100℃)
- Organic solvent friendly
- Widely used across many commercial applications
APIs:
- Molnupiravir
- Trandolapril
- Amino hydroxypiperidine derivatives
- Pimecrolimus
Agro intermediates
- S-metolachlor and S-dimethenamid – Herbicide intermediate (S)-MOIPA
Mode of action
Stereoselective hydrolysis of esters, transesterification, and esterification of acids, and acylation of amines.
Physical form (recyclability)
Immobilized granulate (Yes)
Optimal usage conditions - pH, temperature
5-9, 30-60°C
Commercial applications
APIs:
- Molnupiravir
- Trandolapril
- Amino hydroxypiperidine derivatives
- Pimecrolimus
Agro intermediates
- S-metolachlor and S-dimethenamid – Herbicide intermediate (S)-MOIPA
IMPORTANT INFORMATION
Novonesis does not promote or support the use of enzymes as Active Pharmaceutical Ingredients (APIs) or excipients. Novozymes enzymes are industrial bulk products and are not produced according to pharmaceutical standards. Novozymes does not analyze all impurities and/or carry over in the enzyme product. If enzymes are used as process aids, it is the responsibility of the API or excipient manufacturer to assure that the enzymes are suitable for the intended use, including but not limited to evaluation of purity and absence of carry over in final API or excipient product.
This product contains enzymes. While enzymes are safe to use in consumer applications, they need correct handling in working environments to ensure workers’ safety.
Indeed, repeated inhalation of enzyme dust or aerosols resulting from improper handling may induce sensitization and may cause allergic type 1 reactions in sensitized individuals.
Please follow the precautionary handling recommendations below:
- Avoid breathing dust/fume/gas/mist/vapors/spray
- Avoid contact with eyes, skin, or clothing
- In case of inadequate ventilation wear respiratory protection
- IF INHALED: Remove person to fresh air and keep comfortable for breathing
- If experiencing respiratory symptoms: Call a POISON CENTER or a doctor
- Store in a dry place. Store in a closed container
- Dispose of contents/containers in accordance with local regulations
For recommendations on how to safely handle the enzyme product, please visit the guide.
FAQ
Sustine® 110 IM works well in neat liquid substrates and aqueous mediums, as well as in a wide range of organic solvents.
Optimal test results, including maximum number of recycles, are observed at 30–60°C. However, the temperature range for product activity spans from 20°C to 100°C.
The product is well-suited for both.
Testing one of our products in your own production is the best way to experience all the benefits.
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