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Looking for a stable spore probiotic?

Stay compliant. Stay competitive.

ProSilience™ HU58™ is a reliable Bacillus subtilis probiotic available for foods and beverages across major markets, including the EU and USA. It offers superior stability during processing, surviving pasteurization, and maintains potency throughout your product's shelf-life.

Easy to implement, it enables claims similar to Bacillus coagulans.

Stay competitive in the probiotic market

Consumers are increasingly looking for health benefits in their food and drinks, making probiotics a popular ingredient. However, the complex regulatory landscape poses challenges for manufacturers, including compliance risks, market disruptions, and potential reformulations as regulations change.

ProSilience™ HU58™ offers the strategic advantage you need

  • Health

    Proven health benefits

    Backed by clinical data, HU58™ is demonstrated to support digestive and immune health, allowing you to make claims that resonate with today's consumers.

  • Stability

    Superior stability

    This highly resilient spore-forming probiotic survives demanding processes like pasteurization and maintains its cell count through your product's shelf life, even at ambient temperatures.

  • Regulatory

    Regulatory compliance

    As a Bacillus subtilis strain, ProSilience™ HU58™ is available for sale in the EU, USA and other major markets. We provide regulatory guidance to ensure your success.

  • Implementation

    Seamless implementation

    Switching from Bacillus coagulans to ProSilience™ HU58™ is simple. You can transition quickly while maintaining your product's sensory experience and existing health claims. 

Get in touch with our experts and unlock the exclusive benefits of ProSilience™ HU58™ today

A probiotic trusted by
the industry

Learn how Danish kombucha producer Læsk enhanced their product with ProSilience™ HU58™.

Læsk says that beyond an incredibly heat-stable probiotic, Novonesis offers "unparalleled" commercial and regulatory support, which they call a game-changer for navigating strict markets like Denmark.

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A history of safety and compliance

Bacillus subtilis has a more robust and well-documented history of safe use in food than Bacillus coagulans. ProSilience™ HU58™ includes the species Bacillus subtilis, which has been used for food enhancement for thousands of years across diverse culinary traditions.

This versatile microorganism is recognized in national lists of microorganisms authorized for use in the food chain and is included in the International Dairy Federation (IDF) and European Food and Feed Cultures Association (EFFCA) inventory of microbial food cultures with demonstrated safety in fermented food products.

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Excellent stability from production to consumption

What truly sets ProSilience™ HU58™ apart is its exceptional stability. This resilient spore-former delivers 1 billion CFU through end of product shelf-life and withstands intense food and beverage processing challenges. It even survives pasteurization, boiling water and other heat-applications, enabling stable use in RTDs.

Whether your products are distributed chilled or at ambient temperature, HU58™ helps you maintain high probiotic cell count that support consumer well-being and reinforce your brand’s commitment to quality from production to consumption.

ProSilience™ HU58™ delivers significantly better stability through high-heat pasteurization compared to common B. coagulans strains.

Explore the clinical evidence behind ProSilience™ HU58™

Backed by pre-clinical and clinical studies covering digestive and immune health, ProSilience™ HU58™ helps you transform your products with claims that build consumer trust and drive innovation in the beverage industry.

Download our clinical summary to learn more about ProSilience™ HU58™ and join a healthier tomorrow.

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Endless innovation opportunities

ProSilience™ HU58™ is viable in a broad range of applications.

Take the next step with confidence

By partnering with Novonesis, you gain a team of experts dedicated to your success. Our regulatory experts are ready to guide you on how to label ProSilience™ HU58™ on pack and our technical experts are ready to test and seamlessly implement the probiotic into your production.

Fill in the form, and one of our experts will reach out to you shortly.

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This communication is intended for business-to-business professionals only.

It is not intended for consumers of final consumer goods. Nothing on this page is meant to be perceived as an approved claim. Not all products are available in all countries. Please contact us to learn about product availability in your country.