Class: Human Milk Oligosaccharide (HMO)

Format: Powder

MyOli® 2'-FL (2′-Fucosyllactose)

Disclaimer: Packaging in images is for visual representation only and may not reflect actual product packaging.

2'-FL has been studied more than any other HMO, and with positive outcomes for people of all ages. Research shows that it provides a variety of health benefits ranging from acting as a prebiotic¹to supporting healthy cholesterol². In fact, it has the broadest range of health benefits of any HMO, including language development and brain formation³,⁴.

While concentrations vary widely, 2'-FL is the most abundant HMO in mother’s milk and can easily represent 32% of the overall HMO amount⁵. As with most HMOs, 2'-FL decreases over time during lactation, but it typically remains the predominant HMO in breast milk⁶.

ABOUT HMOs: The third largest component of mothers’ milk solids, HMOs are unlike regular sugars and don’t provide energy to the infant. Rather, they are prebiotics that feed an infant’s microbiota. They are also bioactive and deliver direct health benefits on their own. Every mother’s milk has a unique combination of HMOs, dependent on genetics, nutrition, lactational stage, mother’s lifestyle, geography and more⁷.

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Product features, details and benefits

Benefits

Makes up 20-30% of HMOs in breast milk

Associated with health benefits like supporting growth of commensal bacteria and cognition development

Has immune nourishing prebiotic properties

Study suggests it may confer health benefits to people of all ages

Most abundant and most studied HMO

Details

Product benefits of MyOli® HMO powder:  

Rapid solubility: Dissolves quickly in water without caking  
Exceptional wettability: Ensures easy dispersion in liquid preparations  
Superior flow properties: Simplifies processing steps like filling, sieving, weighing and transport  
High microbial quality: Includes low endotoxin levels for optimal safety.
Neutral taste and odor, without acetic notes

MyOli® 2'-FL is available for wet blend, dry blend and for hypoallergenic application.

Produced in a certified GMP Facility, FSSC22000 certified incl. ISO22000

The MyOli® logo can be used on packaging subject to agreement. MyOli® is a trademark of Chr. Hansen A/S, part of Novonesis Group

Format

This product contains microbials. While microbial products are safe to use in consumer applications, they must be handled correctly in production environments to ensure that workers do not inhale organic dust and bioaerosols.

Please follow the precautionary handling recommendations below:

Avoid breathing dust/fume/gas/mist/vapors/spray
Avoid contact with eyes, skin, or clothing
In case of inadequate ventilation wear respiratory protection
IF INHALED: Remove person to fresh air and keep comfortable for breathing
Store in a dry place. Store in a closed container
Dispose of contents/containers in accordance with local regulations

For recommendations on how to safely handle the microbial product, please visit the guide.

Market availability

Please note that as the manufacturer, it is your responsibility to check and comply with local regulations relevant for selling and use of claims in the relevant market.

Depending on your region, MyOli® HMOs are allowed to be used as:

Functional food ingredient in infant nutrition
General functional nutrition
Food for special medical purpose (FSMP).

MyOli® 2'-FL is available in China, EU, USA, and 27 other countries.

If your market is not listed, please contact us. Market availability is developing constantly.

Health benefits

GUARDS AGAINST UNWANTED MICROBES
HMOs have multiple methods to rid the body of unwanted microorganisms, such as acting as decoys or altering epithelial cell gene expression⁸, ⁹. Each HMO has a highly specific mode of action¹⁰.

2'-FL acts as a soluble receptor decoy that mimics the structures of epithelial cell surfaces. This attracts unwanted microbes and reduces their attachment to intestinal and respiratory epithelial cells. Based on this mechanism, emerging science indicates 2’-FL may contribute to promoting gut comfort¹¹.

ESTABLISHES AN OPTIMAL GUT MICROBIOME

HMOs are prebiotics that promote beneficial bacteria growth⁹,. Long known to attract the healthy Bifidobacteria, recent studies highlight that over 100 non-Bifidobacterium species also use HMOs for their growth. These bacteria then thrive and produce the metabolites necessary to support good health¹².

2'-FL is a key probiotic nutrient for the infant microbiome; it selectively attracts bacteria beneficial to the early-life microbiome, including many Bifidobacterium Infantis and Bifidobacterium Bifidum species. It can also be utilized by other health promoting bacteria such as Akkermansia muciniphila and Bacteroides species^20-22. As a result, 2'-FL may help shift the gut microbial composition toward the pattern typically seen in breastfed infants^23,24.

PROMOTES A HEALTHY GUT
HMOs may promote mucus production²⁵, thereby supporting the physical barrier between the intestinal epithelium and gut content. As well, metabolites produced by HMO fermentation, like short-chain fatty acids, can modulate the immune system and strengthen the gut barrier²⁶.

2'-FL seems to be one of the best HMOs at supporting gut barrier protection²⁷. Following a challenge, 2'-FL increased mucin production in goblet cells, which are known to strengthen the intestinal barrier²⁵.

In addition, it selects for growth of Bifidobacterium strains; these in turn ferment the HMOs and produce metabolites such as short-chain fatty acids. These metabolites can further contribute to strengthening the intestinal barrier^28,29.

MATURES THE IMMUNE SYSTEM
HMOs interact with immune cells both locally in the intestine and systemically, supporting immune cell balance and immune signaling pathways. Their effects are mediated both via direct interactions with immune cells and via metabolites generated during HMO fermentation.

Clinical publications have reported 2'-FL to promote respiratory comfort in infants^11.30. It’s immune-related mechanisms are likely multifactorial. It modulates immune responses, for example by influencing TLR-3 and TLR-4 receptors^15,31 as well as various T cells²⁶. And it can reduce the number of immune modulating cytokines³⁰. 2'-FL has been found systemically, both in plasma and urine³⁰.

In addition, 2'-FL may support immune function indirectly by promoting the formation of immunomodulatory microbial metabolites¹⁰.

SUPPORTS BRAIN DEVELOPMENT AND COGNITION
HMOs are a source of sialic acid and fucose, both of which are essential components for brain development. They also play key roles in neurological processes. A small proportion of certain HMOs can enter the bloodstream, where they may exert positive systemic effects. In addition, HMOs are fermented into microbial metabolites that influence the microbiota–gut–brain axis.

As mentioned earlier, 2'-FL can enter systemic circulation, suggesting that it exerts systemic effects³². It’s been shown to be linked with roles in brain development³³. Early exposure to 2'-FL has been positively associated with motor skill development scores³⁴. Higher levels of 2'-FL in early life are also associated with improved cognitive development scores in infants^5,35.

PERFORMANCE IN ADULTS
2'-FL has been investigated in multiple adult clinical studies. The available data demonstrate beneficial effects across several physiological systems³. It shows clear prebiotic activity by increasing beneficial bacteria and thereby promoting the production of favorable microbial metabolites, such as SCFAs. SFCAs have been detected in both stool and blood samples^2,36. 

Clinical studies report improvements in gastrointestinal quality of life¹, mood³⁷, weight management³⁸ and weight management, and supporting healthy insulin and HDL-cholesterol ¹.

See what science tells us

HMOs represent the beginning of complex processes where it's difficult to determine cause and effect. Much more research is needed to clarify their individual and collective benefits. Here’s a summary of what we know now.

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