Class: Human Milk Oligosaccharide (HMO)
Format: Powder
MyOli® 3-FL (3-Fucosyllactose)
Research indicates that 3-FL enhances intestinal gut barrier function1 and influences immune development1.
It’s unique in that, while the amount of most HMOs decreases over time, 3-FL increases and can approach similar concentrations to 2’-FL. This indicates age-specific relevance. In some mothers’ milk, 3-FL becomes the most abundant HMO. Interestingly, all mother’s milk worldwide follows this trajectory2.
ABOUT HMOs: The third largest component of mothers’ milk solids, HMOs are unlike regular sugars and don’t provide energy to the infant. Rather, they are prebiotics that feed an infant’s microbiota. They are also bioactive and deliver direct health benefits on their own. Every mother’s milk has a unique combination of HMOs, dependent on genetics, nutrition, lactational stage, mother’s lifestyle, geography and more3.
Product features, details and benefits
- Second most abundant fucosylated HMO
- Averages 7% of HMOs in breast milk
- Amount increases during lactation and can become the most prevalent HMO at 6-12 months
- Supports the gut barrier by strengthening epithelial integrity
Product benefits of MyOli® HMO powder:
- Rapid solubility: Dissolves quickly in water without caking
- Exceptional wettability: Ensures easy dispersion in liquid preparations
- Superior flow properties: Simplifies processing steps like filling, sieving, weighing and transport
- High microbial quality: Includes low endotoxin levels for optimal safety.
- Neutral taste and odor, without acetic notes
My Oli® 3 is available for wet blend.
Produced in a certified GMP Facility, FSSC22000 certified incl. ISO22000.
The My Oli® logo can be used on packaging subject to agreement. My Oli® is a trademark of Chr. Hansen A/S, part of Novonesis Group.
This product contains microbials. While microbial products are safe to use in consumer applications, they must be handled correctly in production environments to ensure that workers do not inhale organic dust and bioaerosols.
Please follow the precautionary handling recommendations below:
- Avoid breathing dust/fume/gas/mist/vapors/spray
- Avoid contact with eyes, skin, or clothing
- In case of inadequate ventilation wear respiratory protection
- IF INHALED: Remove person to fresh air and keep comfortable for breathing
- Store in a dry place. Store in a closed container
- Dispose of contents/containers in accordance with local regulations
For recommendations on how to safely handle the microbial product, please visit the guide.
Market availability
Please note that as the manufacturer, it is your responsibility to check and comply with local regulations relevant for selling and use of claims in the relevant market.
Depending on your region, MyOli® HMOs are allowed to be used as:
- Ingredient in infant nutrition
- General nutrition
- Food for special medical purpose (FSMP).
MyOli® 3-FL is available in EU, USA, Hong Kong, and 12 other countries.
If your market is not listed, please contact us. Market availability is developing constantly.
Health benefits
GUARDS AGAINST UNWANTED MICROBES
HMOs have multiple methods to rid the body of unwanted microorganisms, such as acting as decoys or altering epithelial cell gene expression4, 5. Each HMO has a highly specific mode of action6.
3-FL acts as a soluble receptor decoy and blocks microbial attachment to epithelial surfaces. This reduces the initial step of colonization. HMOs are so specialized that, for example, 3-FL can inhibit S. fyris, but not S. enterica, while 2’-FL does the opposite5. 3-FL also acts against undesired viruses, such as Norovirus7.
ESTABLISHES AN OPTIMAL GUT MICROBIOME
HMOs are prebiotics that promote beneficial bacteria growth6, 8. Long known to attract the healthy Bifidobacteria9, 10, recent studies highlight that over 100 non-Bifidobacterium species also use HMOs for their growth11. These bacteria then thrive and produce the metabolites necessary to support good health10.
3-FL is utilized by the infant gut microbiota to selectively promote the growth of certain strains of B. longum, B. bifidum, and B. scardovii. The bifidobacteria then produce metabolites such as lactate and short-chain fatty acids, demonstrating a selective prebiotic effect12, 13.
PROMOTES A HEALTHY GUT
HMOs may promote mucus production14, thereby supporting the physical barrier between the intestinal epithelium and gut content. As well, metabolites produced by HMO fermentation, like SFCAs, can modulate the immune system and strengthen the gut barrier15.
3-FL has been shown to help mature the intestinal barrier function16. And like 2’-FL, 3-FL enhances production of mucins and mucosa-protective proteins by influencing goblet cells (highly specialized cells responsible for mucus secretion in the gut)14.
MATURES THE IMMUNE SYSTEM
HMOs interact with immune cells both locally in the intestine and systemically, supporting immune cell balance and immune signaling pathways. Their effects are mediated both via direct interactions with immune cells and via metabolites generated during HMO fermentation.
3-FL exerts immunomodulatory effects by influencing immune cell signaling. For example, it can increase IL-6 and IL-23 secretion and activate TLR-2. Together, these may help regulate the intensity of the immune response17.
In addition, 3-FL affects T-cell development and balance, thereby influencing adaptive immunity, which is essential for healthy immune system development18.
SUPPORTS BRAIN DEVELOPMENT AND COGNITION
HMOs are a source of sialic acid and fucose, both of which are essential components for brain development. They also play key roles in neurological processes. A small proportion of certain HMOs can enter the bloodstream, where they may exert positive systemic effects. In addition, HMOs are fermented into microbial metabolites that influence the microbiota–gut–brain axis.
3-FL may support early brain development. It’s been associated with effects on early brain tissue organization, particularly in promoting white matter maturation, which is essential for efficient signal transmission within the brain19.
PERFORMANCE IN ADULTS
3-FL has not yet been studied in adult populations; however, clinical research is currently underway.
Importantly, the current lack of published data does not imply a lack of potential benefit. Many of the underlying mechanisms observed in infants, particularly those related to immune and microbiome modulation as well as gut health, are also relevant in later life stages. More data is expected in the future.
See what science tells us
HMOs represent the beginning of complex processes where it's difficult to determine cause and effect. Much more research is needed to clarify their individual and collective benefits. Here’s a summary of what we know now.
MyOli® 3-FL together with probiotics
Children’s gastrointestinal health
MyOli® 3-FL is part of our MyOli® 5 HMO Mix, which is custom blended for your specific target market.
Get in touch
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More about HMO science
Breastmilk is the gold standard in infant nutrition. A major difference between milk from humans and other mammals is the amount and abundance of oligosaccharides. Back in 2015, when we were the first to make HMOs commercially available with our MyOli brand®, HMOs were mainly known for their prebiotic benefits.
Breast milk nourishes baby’s microbiome
Mother’s milk has evolved to give a baby and its microbiome a good start in life. Human milk oligosaccharides can’t be digested by the body— only by bacteria in microbiome.
HMOs comprise about 10% of milk solids and are the third largest solid component.
Over 200 HMOs belong mainly to three classes
The vast majority of HMOs belong to one of three classes. 65-70% contain fucose and are called Fucosylated HMOs. About 30% are split between Sialylated and neutral, non-fucosylated HMOs. SL HMOs contain sialic acid. Neutral, non-fucosylated HMOs have neither fucose or sialic acid, and are building blocks for more complex molecules5.
Three HMO classes with many health benefits
Each HMO is unique and offers multiple benefits. In general, FL HMOs tend to be good at protecting against unwanted microbes. The sialic acid in SL HMOs is important to brain and cognitive function. Neutral HMOs nurture a healthy microbiome20. This is just the tip of the iceberg for HMO health benefits.
Leading the science
As much as is known about HMO health benefits, more is waiting to be discovered. Some of our own scientists and collaborative partners are world-renowned for their HMO research. We also have a donation program so independent researchers can conduct their own studies.
More information about HMOs
You may find these pages interesting, too.
HMOs for infants and toddlers
HMO health benefits
HMOs for adults
µbiom™ synbiotics
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