Rethinking industrial production in the age of biology

This first article takes a step back to the origins of modern production, following how early material transformation developed into today’s industrial systems, and how biology is now beginning to emerge as an alternative way of making and transforming materials.

The Biosolutions BulletinBulletin9 Min readPublished on Jul. 16, 2026
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This three-part series explores how human production evolved from industrial extraction to emerging biological solutions — and what this shift could mean for the future of materials, industry, and the planet.

The condition of the planet today invites for reflection. Materials that define modern life, such as plastics, industrial chemicals, fertilizers, and fossil fuels, have made our lives easier, more productive, and more globally connected than ever before. They have helped increase food production, enabled new industries, and supported rising living standards across much of the world. Yet these same innovations and the way we produce them are also closely tied to many of the environmental challenges we face today.

What is striking is how recently all these materials were innovated. Most of them only became widely used within the past century, which is barely the blink of an eye in historical terms. Some emerged within the lifetime of our great-grandparents, some of whom are still alive and remember a world that functioned without many of the products we now consider indispensable.

The environmental consequences of these materials and the industrial systems that produce them were noticed early on as well. Earlier generations had already begun to see the warning signs. Today, those signals have grown difficult to ignore.

Passing the industrial legacy on to the next generation

Modern materials have made our life easier, but their production is also problematic. The question now is whether we pass these methods on to the next generation or begin reshaping how we produce and consume. 

As humanity continues to depend on these materials at enormous scale, an important question comes into view: do we simply pass this industrial legacy on to the next generation, or begin searching for new ways to produce what we need while allowing the planet to recover and regenerate?

To explore that question, it helps to step back. To look not just at the materials themselves, but at how this entire system of production came into existence.
 

Extracting and reshaping nature

For most of human history, our ancestors lived in a world where survival depended almost entirely on what nature provided. Stones could be shaped into tools. Wood could be burned for heat. Plants and animals offered food, clothing, and shelter. The natural world was not something humans controlled; it was something they carefully navigated.

Then, at some point in the distant past, a small but remarkable insight changed everything. People discovered that clay, when shaped and exposed to fire, would harden into something entirely new. What began as a soft, fragile material became durable and useful.

This discovery — fired clay — may seem humble today. But it marked a profound shift in human thinking. For the first time, people realized that materials found in nature could be transformed into entirely new forms using heat and human skill. It was one of the earliest instances of humans creating a material that did not exist in nature.

Some of the earliest known examples of fired clay date back over 28,000 years1, discovered near the village of Dolní Věstonice in present-day Czech Republic.

Extracting and reshaping nature

One day our ancestors discovered that clay, when shaped and exposed to fire, would harden into something entirely new. Nothing ever stayed the same after that.  

Once this idea took hold, that new materials could be produced by transforming natural resources, it did not remain confined to clay. Over time, people began to notice that certain stones behaved differently in fire. When heated intensely, they revealed something unexpected — metal. Copper appeared first, soft but workable. Later, by combining copper with tin, people produced bronze, a material stronger and more durable than either metal alone.

For the first time, humans were not just shaping what they found. They were combining elements to produce something entirely new. The Bronze Age had begun.

Centuries later came another breakthrough. Humans learned how to extract iron from ore. Iron tools were stronger, sharper, and more abundant than bronze ones. Farming became more productive. Construction advanced. Entire civilizations were reshaped.

Across these early transformations, a pattern began to emerge. Humans had discovered two powerful capabilities: the ability to extract materials from the Earth, and the ability to transform them using heat, pressure, and skill. As time went on, these capabilities were refined, expanded, and eventually scaled.

By the eighteenth century, humanity had entered the industrial age. Production moved from small, manual processes to large-scale manufacturing powered by machines. Over time, these systems were optimized for speed, efficiency, and output.

But beneath all this progress, one principle remained unchanged. Natural resources were extracted from the Earth and transformed using energy, often in the form of high heat, pressure, and chemical reactions.

As scientific understanding deepened, new resources entered this system. Coal fueled early industrial growth. Steel enabled the construction of railways, bridges, and cities. Then, in the nineteenth century, another resource emerged from deep beneath the Earth, which would reshape the trajectory of human civilization — oil.

When people learned how to extract and refine it, oil became the foundation of modern industry. It powered transportation. It enabled the production of fuels, chemicals, and entirely new materials, like plastics, synthetic fibers, and a vast range of industrial chemicals.

From early clay kilns to modern oil refineries, the underlying pattern remained remarkably consistent:

Dig into the Earth → Extract what lies beneath → Apply energy and ingenuity → Transform it into new products

Over time, this approach became the foundation of human industry, and, in many ways, the foundation of the modern world. At first, it appeared remarkably effective. Resources were transformed into products that improved lives in countless ways. The more we produced, the more progress seemed to follow.

But slowly, a different pattern began to emerge. Many of the materials we produced were not designed to return to the Earth. Once their purpose was fulfilled, they did not disappear. They accumulated in landfills, rivers, oceans.

Extraction continued. Production expanded. But regeneration struggled to keep pace. The system that had powered human progress for centuries followed a simple path:

Take Make Discard

Extract -> Product -> Discard

For a long time, that path seemed sufficient. But as the scale of human activity grew, a new question began to take shape.

What happens when a system built on continuous extraction meets a planet with limits?

And perhaps more importantly — is this the only way to produce?

To answer that, we do not necessarily have to begin with a new invention. We can begin by looking at a system that has been sustaining production and recycling for billions of years: nature.

Long before humans learned to manufacture materials at industrial scale, nature had already been running its own production and recycling system for billions of years.

Unlike many human production systems, nature does not simply extract, produce, and discard. Materials continuously cycle through living systems, where they are broken down and reused again and again.
 

Nature: the master of production and recycling

Life on Earth appeared at least 3.7 billion years2 ago, a span of time so vast that it is difficult to fully grasp. One way to understand it is this: if the entire history of our planet were compressed into a single year, life would emerge around late February, dinosaurs would arrive in mid-December, and humans would enter the scene just before midnight on December 313.

Over these billions of years, Earth has been anything but stable. Continents have drifted, climates have shifted dramatically, and entire groups of species have risen, flourished, and disappeared. Scientists estimate that our planet has experienced at least five major mass extinction events4, each one wiping out vast numbers of living organisms5.

Yet something remarkable followed each of these events: life returned.

What happened to all those living organisms that died? How did the planet recover from such catastrophic losses? The answer lies, in part, in a powerful process that operates continuously across the natural world: nutrient cycling6 — what we might think of as nature’s way of recycling.

When living organisms die, their remains do not simply accumulate indefinitely. Instead, a vast cleanup system gets to work7. Bacteria, fungi, insects, and other decomposers break down complex biological matter into simpler compounds, such as carbon- and nitrogen-based nutrients. These are returned to the soil, water, and atmosphere, becoming the raw materials that support new life.

In nature, every ending quietly becomes the beginning of something new.

You can see a small glimpse of this process even in a backyard garden. Dig a small hole in the soil and bury a banana peel. Return a few months later and dig again. The peel will be gone. The microbes and tiny organisms in the soil will have broken it down completely, turning it into nutrients and energy. Behind this seemingly simple transformation lies one of biology’s most remarkable tools: enzymes.

Enzymes are tiny proteins produced by living organisms that act as catalysts, enabling chemical reactions to occur rapidly under conditions where they would otherwise take years, or even, not occur at all. With the help of enzymes, microbes can break down complex materials such as plant fibers, proteins, and other biological compounds that might otherwise persist in the environment for years.

Now imagine this process not in a small patch of soil, but across forests, oceans, and ecosystems all over the planet, unfolding continuously over millions of years.

Leaves fall and decompose into the soil. Marine organisms live and die in the oceans. Nutrients circulate through ecosystems in vast, interconnected cycles. Through these processes, nature continually breaks down old materials and uses their building blocks to produce new life. Production and recycling keep happening in nature.

Nature- the master of production and recycling

Humans, despite all our technological advances, have struggled to replicate this kind of circular efficiency in production.

The idea of recycling in modern society only gained widespread attention a few decades ago. In 1970, a young graphic design student, Gary Dean Anderson, created the now-famous recycling symbol of three green twisting arrows. That same year also marked the first Earth Day, a sign that people were beginning to recognize the environmental consequences of industrial production.

Gary Dean Anderson created the famous recycling symbol

Only a few decades ago, recycling began to be seriously organized. In 1970, Gary Dean Anderson designed the three-arrow symbol still used internationally today. 

Since then, recycling systems have been developed across the world. Regulations have been introduced. Waste management practices have improved.

Yet truly circular systems remain difficult to achieve.

Globally, only ten percent of plastic is recycled

Globally, only a small fraction of plastic waste — less than ten percent8 — is recycled, and most of it ends up disposed of in nature. Many materials that we recycle lose quality each time they are reused. Plastics and textiles often need to be mixed with newly produced resources to maintain their properties.

In other words, while nature has spent billions of years perfecting a system in which materials are continuously reused, human industry is still struggling to close the loop.

And this contrast leads to an important realization: the challenge is not simply improving our recycling systems, but to rethink how we produce things in the first place.

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When push comes to shove, rethinking production

It is easier to admire nature’s circular efficiency than to rebuild human production around it.

The industrial production system we have in place today is not new. Its foundations were laid centuries ago, then refined over time to become fast, efficient, reliable, and scalable. Factories, supply chains, infrastructure, investments, and regulations have all grown around this way of producing, making it deeply embedded in how modern industry works.

These systems work. They are familiar, well understood, and difficult to replace. Changing them requires not just new ideas, but new ways of thinking, new systems, and often, new infrastructure.

For a long time, there was little reason to make that change. But history shows that when circumstances shift, so do the methods of production we rely on.

One of the earliest and most striking examples of this shift emerged during the First World War.

At the time, the British military depended on a substance called cordite, which was used to fire ammunition. The production of cordite required acetone, an essential chemical that Britain largely obtained through processes linked to raw materials imported from Germany. When war disrupted these supply chains, a crisis emerged. Without acetone, the British could not fire their weapons at scale.

This forced a search for alternatives, and the answer came from an unexpected place — biology. Scientists had long known about fermentation. It had been used for centuries to produce bread, beer, and wine. But it had not yet been used as a large-scale industrial method to produce chemicals.

That changed with the work of Chaim Weizmann9. Weizmann discovered that a bacterium — Clostridium acetobutylicum — could convert starch into acetone through fermentation. Instead of relying on resource-intensive chemical processes, this method used living organisms to produce the same compound. When this process was scaled, it provided a reliable domestic source of acetone, which helped the British sustain their wartime production and made them more self-reliant.

Chaim Weizmann - the father of industrial fermentation

As early as World War I, Weizmann's acetone fermentation process showed that microorganisms could replace high-temperature chemical manufacturing. 

However, the significance of this shift in production mechanism went beyond the wartime logistical challenges and necessities. There was an environmental angle too.

Before fermentation was introduced, acetone was produced by heating calcium acetate, derived from timber, at temperatures of around 380°C10, breaking it down through a series of chemical steps. By contrast, the fermentation route operated under much milder conditions. While higher temperatures (around 140°C) were required to sterilize the plant-based starch feedstock, such as maize, the fermentation process itself took place at a temperature of 35–37°C11.

Although this shift was driven by necessity rather than environmental intent, it revealed something important. A process that depended on sustained high heat, multiple chemical steps, and resource-intensive inputs could be replaced by one that required far less energy and worked with living organisms, using biological processes to produce the same outcome.

Over time, this idea was adopted and expanded across the world. Countries began to use fermentation as a production mechanism to produce other important compounds, including chemicals such as citric acid, antibiotics such as penicillin, and later, essential medicines like insulin.

Fermentation also enabled the production of enzymes, which power many biological processes in nature. This made it possible for the industries to incorporate enzymes into a wide range of production processes. In many cases, this biological approach reduced the need for energy-intensive conditions and harsh chemicals, offering more efficient and environment-friendly ways of producing everyday materials and products12.

These advances are even paving the way for new approaches to even plastic recycling13, where certain plastics can be broken down into their original building blocks and reused to create new materials, moving a step closer to more circular production.

Taken together, these examples point to a different way of producing, where biology is used to make, break down, and transform materials. Approaches like these, where natural biological processes such as fermentation and natural tools like enzymes are used in industrial production and material recycling, are increasingly known as biosolutions.

These developments marked a gradual but important shift. From forcing materials into new forms through extreme heat and chemistry, to guiding biological processes under milder conditions to produce what we need. In many ways, this is the essence of biosolutions — working with biology, rather than against it, to meet human needs.

These examples are not isolated moments in history. Together, they point to a broader shift in modern industry, where biology is gradually moving from the margins of production into the mainstream.
 

A shift already underway

Fermentation is no longer just a process used to bake bread or brew beer. Today, it is used across industries, from pharmaceuticals and biofuels to agriculture and chemicals. Enzymes produced through fermentation find their way into the production of around 40014 everyday products, spanning 4015 industrial sectors. This points to something larger — industrial production is beginning to take a more biosolutions-based approach.

And that shift is not happening in isolation. The condition of our planet is beginning to shape how we produce, what we produce, and the choices we make along the way. In that context, biosolutions are not just an alternative, but a way of bringing production closer to how nature has worked all along.

But transitions of this scale are never straightforward. The shift from an industrial-age production mindset to a biological one is slowed by many factors. So, the question is no longer whether biology can help reshape production. It is why, despite all this promise, the transition is still not moving faster.

To answer that, we have to step into the next part of the story: Biology, Regulation, and the pace of progress.

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One machine behind the Industrial Revolution

One machine behind the Industrial Revolution: 
One of the main drivers of the Industrial Revolution was the steam engine designed by James Watt in 1769. The Watt steam engine produced more power and could regulate it with far greater efficiency than earlier models. By 1800, Watt had sold over 500 machines. Variations of this design would power industries for more than a century, quietly reshaping how production worked across the world.16

Demon escapes from a DNA lab?
In 1977, reports of a strange, orange-eyed creature in Dover, Massachusetts, later nicknamed the “Dover Demon”, sparked curiosity and a bit of panic. Cambridge mayor Alfred Vellucci quickly joined the dots, publicly wondering whether it could be the result of recombinant DNA experiments at nearby Harvard labs, invoking images of Dr. Frankenstein. He even wrote to the National Academy of Sciences about possible lab escapes. What sounded like science fiction reflected something very real — how quickly unfamiliar science can turn into something far more unsettling in the public imagination.

Most likely a misidentified animal or a mistaken sighting, the mystery was never solved.17

article credits
Read part two

Biology, regulation, and the pace of progress

Biosolutions can support more sustainable production, but complex and fragmented regulatory pathways can slow adoption. Explore how today’s frameworks were shaped — and why coordination matters. 

What is a biosolution?

Microbes and enzymes are tiny but mighty agents of change. For billions of years, they’ve enabled transformation in all living things through microbiology.

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References: 

1. The first artificial material: Ceramics from prehistory to the fall of rome. https://pubs.acs.org/doi/10.1021/bk-2015-1211.ch003  

2. World's oldest fossils unearthed. https://www.ucl.ac.uk/news/2017/mar/worlds-oldest-fossils-unearthed 

3. The geologic time scale. Kentucky Geological Survey. https://www.uky.edu/KGS/education/geologictimescale.pdf  

4. How earth’s biggest mass extinctions stack up. https://www.scientificamerican.com/article/how-earths-biggest-mass-extinctions-stack-up/ 

5. Mass extinctions through geologic time. https://www.nps.gov/subjects/fossils/mass-extinctions-through-geologic-time.htm  

6. Material cycling in ecosystems. https://www.bbc.co.uk/bitesize/guides/zg74xfr/revision/1  

7. Decomposers in Ecosystems: Types, Roles & Examples. https://microbenotes.com/decomposers-definition-types-examples/  

8. Why aren’t we recycling more plastic? https://stories.undp.org/why-arent-we-recycling-more-plastic 

9. Chaim Weizmann’s Acetone Discovery was Key to British WWI Effort. https://www.weizmann-usa.org/blog/chaim-weizmann-s-acetone-discovery-was-key-to-british-wwi-effort/ 

10. How Biotechnology Helped Maintain the Supply of Acetone for the Manufacture of Cordite During World War I. https://www.tandfonline.com/doi/abs/10.1179/1758120614Z.00000000043 

11. United States Patent Office. https://patentimages.storage.googleapis.com/7c/4d/35/ef433a9f1b4247/US1315585.pdf 

12. Enzymes at work: Let’s learn through some examples. https://www.novonesis.com/en/news/the-biosolutions-bulletin-02-enzymes-at-work-lets-learn-through-some-examples  

13. Digesting the problem: Enzymes chew through plastic pollution. https://www.novonesis.com/en/news/the-biosolutions-bulletin-02-digesting-the-problem-enzymes-chew-through-plastic-pollution 

14. Enzyme applications. amfep. https://amfep.org/about-enzymes/applications  

15. Strategies and Challenges for the Development of Industrial Enzymes Using Fungal Cell Factories. https://pmc.ncbi.nlm.nih.gov/articles/PMC7123961/#:~:text=used%20in%20over-,40%20industry%20sectors,-%2C%20from%20household%20care  

 

Fun facts references:

16. Watt Steam Engine
https://www.worldhistory.org/Watt_Steam_Engine/

17. Harvard’s “Frankenstein:” The 70s Controversy Over Mixing DNA
https://gizmodo.com/harvards-frankenstein-the-70s-controversy-over-mixin-1693900253