From stomach to gut, consumers want gentle, science-backed ways to keep their digestive system in balance despite modern lifestyle challenges. You can help.
The way we live can affect both the stomach and the gut. And if the stomach lining is under pressure or the gut is leaky, the gut’s natural defenses can be weakened.
Give health-conscious consumers gold standard probiotics to support a robust gut.
For consumers looking for a stable and effective probiotic to promote gut integrity, L. rhamnosus, LGG™ is a good bet. It’s been used worldwide since 1990 to keep the gut in check. It promotes microbial balance by outcompeting unwanted bacteria1-4, as well as supporting a healthy intestinal barrier5-6 and immune health7-9.
Up to 44% of the world's population carry a specific stomach bacterium. For some, this may make maintaining a healthy gastric environment an area of particular interest.
Pylopass™ is a scientifically documented postbiotic designed to support gastric health through a targeted interaction with specific microorganisms in the stomach.
Bifidobacteria are an important player in the gut microbiome10. For example, they feed butyrate-producing bacteria that support gut health. But the older we get, the fewer Bifidobacteria we have.
So, for consumers who want to give their gut an extra advantage, we recommend a synbiotic that starts with clinically documented Bifidobacteria. Then add a MyOli™ HMO, designed by nature to encourage Bifidobacterium growth in the human gut11.
Use BB-12® + Istilos™ + MyOli™ 2'-FL to:
HMOs are nature’s way to support a healthy microbiome. A study has shown that using MyOli™ 2'-FL can increase the abundance of Bifidobacteria up to three- fold18.
Many people strive to support their overall health every day, even when it comes with occasional challenges. For example, individuals focused on heart health often mention concerns about maintaining digestive comfort.
Imagine a natural way to nurture your body’s balance and support digestive well-being. In a leading clinical trial, Galenex™, B. Breve was shown to promote a healthy intestinal lining and contribute to overall gut balance.
How are you capitalizing on trends for more CFUs?
A healthy gut barrier is key for a well-functioning gastrointestinal system. But intestinal permeability affects other health areas, too.
That’s why you can combine gut health with other health areas to produce a unique and truly beneficial product for your consumers.
Since the gut microbiota play an important role in developing and maintaining our immune system, gut and immune health can be an attractive positioning for your product.
Gut health and heart health can go hand in hand. Check out our other products for heart health and get inspired to develop your one-of-a-kind product for people focused on their heart health.
The rhythms of life affect a woman’s gut. Regularity can fluctuate in connection with menstrual cycles22, not to mention pregnancy. And as she ages, she naturally loses beneficial Bifidobacteria. So benefits for gut resilience in a woman’s biosolution could be a good bet.
Whatever it is, let us know. Together, we can help people with their gastrointestinal discomfort. It’s a question of better health.
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1. De Keersmaecker et al., Strong antimicrobial activity of Lactobacillus rhamnosus GG against Salmonella typhimurium is due to accumulation of lactic acid. FEMS Microbiol Lett. 2006 Jun;259(1):89-96.
2. Lu et al., Isolation, identification, and characterization of small bioactive peptides from Lactobacillus GG conditional media that exert both anti-Gram-negative and Gram-positive bactericidal activity. J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):23-30.
3. Tytgat et al., Lactobacillus rhamnosus GG Outcompetes Enterococcus faecium via Mucus-Binding Pili: Evidence for a Novel and Heterospecific Probiotic Mechanism. Appl Environ Microbiol. 2016 Sep 16;82(19):5756-62.
4. Petrova et al.,. Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation. PLoS One. 2016 Aug 18;11(8):e0161337.
5. Leser et al., Molecular Mechanisms of Lacticaseibacillus rhamnosus, LGG® Probiotic Function. Microorganisms. 2024 Apr 14;12(4):794.
6. Yan eet al., Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology. 2007 Feb;132(2):562-75.
7. Kekkonen et al., Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults. World J Gastroenterol. 2008 Apr 7;14(13):2029-36.
8. Pagnini et al., Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study. World J Gastroenterol. 2018 Nov 7;24(41):4652-4662.
9. Schultz et al., Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain GG in healthy volunteers. J Dairy Res. 2003 May;70(2):165-73.
10. Frontiers | Trophic Interactions of Infant Bifidobacteria and Eubacterium hallii during L-Fucose and Fucosyllactose Degradation
11. Gotoh et. al. Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum. Sci Rep. 2018 Sep 18;8(1):13958.
12. Eskesen et. al. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr. 2015 Nov 28;114(10):1638-46.
13. Pitkala et. al. Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial. J Nutr Health Aging. 2007 Jul-Aug;11(4):305-11. PMID: 17653486.
14. Uchida, et al. Effect of fermented milk containing Bifidobacterium lactis Bb-12 on stool frequency, defecation, fecal microbiota and safety of excessive ingestion in healthy female students -2nd report. J Nutr Food 2005:39-51.
15. Schwab et al. Trophic Interactions of Infant Bifidobacteria and Eubacterium hallii during L-Fucose and Fucosyllactose Degradation. Front Microbiol. 2017 Jan 30;8:95.
16. Peng et al. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr. 2009 Sep;139(9):1619-25.
17. Willemsen et al. Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblasts. Gut. 2003 Oct;52(10):1442-7.
18. Elison et. al. Oral supplementation of healthy adults with 2'-O-fucosyllactose and lacto-N-neotetraose is well tolerated and shifts the intestinal microbiota. Br J Nutr. 2016 Oct;116(8):1356-1368.
19. Novonesis consumer survey, Mar 2019. Base: Everyday aspirin users
20. Mortensen et al. Bifidobacteriumbreve Bif195 Protects Against Small-Intestinal Damage Caused by Acetylsalicylic Acid in Healthy Volunteers. Gastroenterology. 2019 Sep;157(3):637-646.e4.
21. Løn et al. Bifidobacterium breve Bif195 ameliorates aspirin-induced gastric mucosal damage: A randomised, double blind, placebo-controlled crossover trial. Aliment Pharmacol Ther. 2024 Feb;59(3):341-349
22. Turnbull et al. Relationships between symptoms, menstrual cycle and orocaecal transit in normal and constipated women. Gut. 1989 Jan;30(1):30-4.