Class: Human Milk Oligosaccharide (HMO)
Format: Powder
MyOli® 5HMOMIX™
Our Novonesis MyOli™ 5HMOMIX™ contains HMOs selected for their importance to infant health. The complex blend represents all three HMO categories, (fucosylated, sialylated and neutral HMOs). MyOli™ 5HMOMIX™ is the most researched complex blend on the market, backed by multiple clinical studies.
Infant formula with MyOli™ 5HMOMIX™ has been shown to be safe and well-tolerated1. More studies are in progress, including on further effects for a healthy start in life as well as for healthy longevity. It’s already acknowledged by ESPGHAN2, 3to support gut health, stooling patterns and to have stool softening effects in infants.
ABOUT HMOs: The third largest component of mothers’ milk solids, HMOs are unlike regular sugars and don’t provide energy to the infant. Rather, they are prebiotics that feed an infant’s microbiota. They are also bioactive and deliver direct health benefits on their own. Each mother’s milk has a unique combination of HMOs, dependent on genetics, nutrition, lactational stage, mother’s lifestyle, geography and more4.
Product features, details and benefits
- Offers benefits of several key HMOs
- Most researched HMO blend that represents all key structure groups
- Shifts microbiome composition closer to that of breastfed infants
- Studies show better overall health for infants consuming it
Product benefits of MyOli™HMO powder:
- Rapid solubility: Dissolves quickly in water without caking
- Exceptional wettability: Ensures easy dispersion in liquid preparations
- Superior flow properties: Simplifies processing steps like filling, sieving, weighing and transport
- High microbial quality: Includes low endotoxin levels for optimal safety.
- Neutral taste and odor, without acetic notes
The MyOli™ 5HMOMIX™ consists of 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), lacto-N-tetraose (LNT), 3′-sialyllactose (3′-SL), and 6′-sialyllactose (6′-SL).
MyOli™ 5HMOMIX™ is available for wet blend, dry blend and for hypoallergenic application
Produced in a certified GMP Facility, FSSC22000 certified incl. ISO22000.
The My Oli™ logo can be used on packaging subject to agreement. My Oli™ is a trademark of Chr. Hansen A/S, part of Novonesis Group.
This product contains microbials. While microbial products are safe to use in consumer applications, they must be handled correctly in production environments to ensure that workers do not inhale organic dust and bioaerosols.
Please follow the precautionary handling recommendations below:
- Avoid breathing dust/fume/gas/mist/vapors/spray
- Avoid contact with eyes, skin, or clothing
- In case of inadequate ventilation wear respiratory protection
- IF INHALED: Remove person to fresh air and keep comfortable for breathing
- Store in a dry place. Store in a closed container
- Dispose of contents/containers in accordance with local regulations
For recommendations on how to safely handle the microbial product, please visit the guide.
Market availability
Please note that as the manufacturer, it is your responsibility to check and comply with local regulations relevant for selling and use of claims in the relevant market.
Depending on your region, MyOli™ HMOs are allowed to be used as:
- Functional food ingredient in infant nutrition
- General functional nutrition
- Food for special medical purpose (FSMP).
MyOli™ 5HMOMIX™ is available in Canada, Hong Kong, India, and 14 other countries.
Since the regulatory landscape is under constant development, please reach out to us for an updated view on your specific market.
Health benefits
GUARDS AGAINST UNWANTED MICROBES
HMOs have multiple methods to rid the body of unwanted microorganisms, such as acting as decoys or altering epithelial cell gene expression5, 6. Each HMO has a highly specific mode of action7.
Combining five key HMO structures into a single blend provides a broad potential for activity against opportunistic, unwanted microbes.
ESTABLISHES AN OPTIMAL GUT MICROBIOME
HMOs are prebiotics that promote beneficial bacteria growth5, 8. Long known to attract the healthy Bifidobacteria9, 10, recent studies highlight that over 100 non-Bifidobacterium species also use HMOs for their growth11. These bacteria then thrive and produce the metabolites necessary to support good health10.
As the microbiota-stimulating effects of HMOs are structure-dependent, combining the five key HMO structures in our MyOli™ 5HMOMIX™ offers strong potential to beneficially modulate the microbiome by selectively promoting desired microbes.
Clinical research has shown that MyOli™ 5HMOMIX™ shifts the gut microbiota composition closer to that of breastfed infants, primarily by increasing the abundance of bifidobacteria, which promote the production of metabolites associated with positive effects12.
PROMOTES A HEALTHY GUT
HMOs may promote mucus production13, thereby supporting the physical barrier between the intestinal epithelium and gut content. As well, metabolites produced by HMO fermentation, like short-chain fatty acids, can modulate the immune system and strengthen the gut barrier14.
MyOli™ 5HMOMIX™ contains five of the most important HMOs for infant development. Together, they contribute to intestinal maturation and strengthen the gut barrier. See the individual product pages for more details.
MATURES THE IMMUNE SYSTEM
HMOs interact with immune cells both locally in the intestine and systemically, supporting immune cell balance and immune signaling pathways. Their effects are mediated both via direct interactions with immune cells and via metabolites generated during HMO fermentation. Via these mechanisms, HMOs contribute to immune system development as well as immune defense15.
SUPPORTS BRAIN DEVELOPMENT AND COGNITION
HMOs are a source of sialic acid and fucose, both of which are essential components for brain development. They also play key roles in neurological processes. A small proportion of certain HMOs can enter the bloodstream, where they may exert positive systemic effects. In addition, HMOs are fermented into microbial metabolites that influence the microbiota–gut–brain axis.
In a clinical trial on infants, MyOli™ 5HMOMIX™ was shown to improve cognitive outcomes compared to infants receiving a formula that did not contain HMOs16.
See what science tells us
HMOs represent the beginning of complex processes where it's difficult to determine cause and effect. Much more research is needed to clarify their individual and collective benefits. Here’s a summary of what we know now.
Get in touch
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More about HMO science
Breastmilk is the gold standard in infant nutrition. A major difference between milk from humans and other mammals is the amount and abundance of oligosaccharides. Back in 2015, when we were the first to make HMOs commercially available with our MyOli™ brand, HMOs were mainly known for their prebiotic benefit.
Breast milk nourishes baby’s microbiome
Mother’s milk has evolved to give a baby and its microbiome a good start in life. Human milk oligosaccharides can’t be digested by the body— only by bacteria in microbiome.
HMOs are the third largest solid component.
Over 200 HMOs belong mainly to three classes
The vast majority of HMOs belong to one of three classes. 70% contain fucose and are called Fucosylated HMOs. Sialylated and neutral HMOs split the remaining 30%. SL HMOs contain sialic acid. Neutral HMOs have neither fucose or sialic acid, and are building blocks for more complex molecules17.
Three HMO classes with many health benefits
Each HMO is unique and offers multiple benefits. In general, FL HMOs tend to be good at protecting against unwanted microbes. The sialic acid in SL HMOs is important to brain and cognitive function. Neutral HMOs nurture a healthy microbiome18. This is just the tip of the iceberg for HMO health benefits.
Leading the science
As much as is known about HMO health benefits, more is waiting to be discovered. Some of our own scientists and collaborative partners are world-renowned for their HMO research. We also have a donation program so independent researchers can conduct their own studies.
More information about HMOs
You may find these pages interesting, too.
HMOs for infants and toddlers
HMO health benefits
HMOs for adults
µbiom™ synbiotics
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