MyOli® 6′-SL (6′-Sialyllactose)

Please note that as the manufacturer, it is your responsibility to check and comply with local regulations relevant for selling and use of claims in the relevant market.

Depending on your region, MyOli® HMOs are allowed to be used as:

• Functional food ingredient in infant nutrition
• General functional nutrition
• Food for special medical purpose (FSMP).

MyOli® 6'-SL is available in EU, USA, Hong Kong, and 13 other countries.

If your market is not listed, please contact us. Market availability is developing rapidly.

GUARDS AGAINST UNWANTED MICROBES
HMOs have multiple methods to rid the body of unwanted microorganisms, such as acting as decoys or altering epithelial cell gene expression⁴, ⁵. Each HMO has a highly specific mode of action⁶.

6'-SL can act as a decoy to attract certain unwanted microbes to attach to it instead of the epithelial surface, thereby ensuring they are flushed out of the system without causing harm⁷, ⁸, ⁹.

ESTABLISHES AN OPTIMAL GUT MICROBIOME 

HMOs are prebiotics that promote beneficial bacteria growth⁴, ¹⁰. Long known to attract the healthy Bifidobacteria, recent studies highlight that over 100 non-Bifidobacterium species also use HMOs for their growth¹¹. These bacteria then thrive and produce the metabolites necessary to support good health¹².

Like other sialylated HMOs, 6'-SL only promotes moderate growth of some bacteria like infant-type Bifidobacterium infantis and B. bifidum¹³, ¹⁴. But it may help maintain stability of the gut microbiota under stress conditions and may exert effects on stress-related behavioral outcomes through modulation of the microbiota-gut-brain axis¹⁵.

PROMOTES A HEALTHY GUT
HMOs may promote mucus production¹⁶, thereby supporting the physical barrier between the intestinal epithelium and gut content. As well, metabolites produced by HMO fermentation, like short-chain fatty acids, can modulate the immune system and strengthen the gut barrier¹⁷.

6'-SL has been shown to promote epithelial cell differentiation and maturation, which may contribute to improved intestinal barrier integrity¹⁸, ¹⁹.

MATURES THE IMMUNE SYSTEM
HMOs interact with immune cells both locally in the intestine and systemically, supporting immune cell balance and immune signaling pathways. Their effects are mediated both via direct interactions with immune cells and via metabolites generated during HMO fermentation.

Like 3'-SL, 6'-SL helps shape immune responses, for example, by promoting TH1 and TH17 responses. These stimulate the immune system to fight. Both 6'-SL and 3'-SL can also reduce TH2 response, which is associated with skin discomfort²⁰.

SUPPORTS BRAIN DEVELOPMENT AND COGNITION
HMOs are a source of sialic acid and fucose, both of which are essential components for brain development. They also play key roles in neurological processes. A small proportion of certain HMOs can enter the bloodstream, where they may exert positive systemic effects. In addition, HMOs are fermented into microbial metabolites that influence the microbiota–gut–brain axis.

6'-SL is, like other sialylated HMOs, a key a source of sialic acid, an essential building block for the brain. It’s also positively associated with cognitive development and motor scores²¹. Beyond that, studies link 6'-SL with supportive effects on brain structure and cognitive outcomes²².

PERFORMANCE IN ADULTS
6'-SL has been evaluated in clinical trials in adult populations, where its safety and tolerability were consistently confirmed, including at daily intakes of up to 6 g².

Beyond safety, clinical research has shown that 6'-SL can enter the systemic circulation. In addition, supplementation has been associated with improvements in proximal muscle power² and a slowing of muscle strength decline¹.